Satellite Cells In Skeletal Muscle Hypertrophy

The role of satellite cells in muscle hypertrophy has long been a debated issue.

Satellite cells in skeletal muscle hypertrophy.

The role of satellite cells in muscle hypertrophy has long been a debated issue. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis giving rise to the idea of a nuclear domain. Through the stimulus overload adaptation cycle muscle tissue has the ability to produce more contractile force store higher levels of substrate improve. The myonuclear number did not change in any group.

There was no change in satellite cells or mnd in the traditional endurance and control groups. Hormones in skeletal muscle hypertrophy hormones are chemicals which organs secrete to initiate or regulate the activity of an organ or group of cells in another part of the body. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis giving. This is a major research finding alas at the molecular level of muscle which shows that skeletal muscle fiber hypertrophy begins to occur before the addition of new muscle nuclei see figure 1.

These data are consistent with the hypothesis that testosterone administration induces skeletal muscle hypertrophy by promoting satellite cell replication and activation resulting in an increased number of myogenically committed satellite cells 23 34 36. Satellite cells lead to. 1 department of physiology and biophysics medical science i d335 university of california irvine ca 92697 usa. An important unresolved question in skeletal muscle plasticity is whether satellite cells are necessary for muscle fiber hypertrophy.

A similar process is induced in adult skeletal muscle by functional overload and exercise. Muscle is a remarkable living tissue it has the amazing potential to adapt to a presented stimulus or functional demand. Satellite cell proliferation and skeletal muscle hypertrophy. Hikida et al 2000.

In contrast satellite cells and myonuclei may undergo apoptosis during muscle atrophy although it is debated whether myonuclear loss occurs in atrophying muscle. These findings have led to a general consensus that satellite cell mediated myonuclear addition is likely an involved mechanism in promoting skeletal muscle hypertrophy and this hypothesis is further supported by studies which have illustrated high associations exist between fcsa and myonuclear number kadi et al 1999. Gradams uci edu satellite cells are small mononuclear cells found in close association with striated skeletal muscles cells myofibers. Following on from part 1 this article looks at the role of satellite cells in the muscle hypertrophy process.